Takao Shimizu Selected Research

Leukotriene B4 Receptors (Leukotriene B4 Receptor)

1/2019	Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice.
1/2019	Correction: Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice.
1/2017	Inhibition of Leukotriene B4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice.
3/2015	The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.
8/2013	Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.
12/2010	Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.
4/2010	The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis.
2/2007	Identification of the intracellular region of the leukotriene B4 receptor type 1 that is specifically involved in Gi activation.
10/2005	Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses.

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Takao Shimizu Research Topics

Disease

26	Inflammation (Inflammations) 12/2017 - 05/2002
8	Neoplasms (Cancer) 06/2022 - 02/2003
7	Pain (Aches) 01/2017 - 07/2004
6	Hepatocellular Carcinoma (Hepatoma) 09/2020 - 12/2018
6	Fibrosis (Cirrhosis) 12/2019 - 05/2006
6	Hypersensitivity (Allergy) 03/2012 - 10/2005
6	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2010 - 09/2005
5	Anaphylaxis (Anaphylactic Shock) 01/2021 - 08/2002
5	Obesity 01/2019 - 06/2003
5	Asthma (Bronchial Asthma) 01/2018 - 01/2002
5	Bone Resorption 12/2009 - 05/2003
4	Ischemia 08/2013 - 08/2002
3	Neuralgia (Stump Neuralgia) 01/2021 - 05/2010
3	Chronic Hepatitis C 05/2020 - 12/2018
3	Leukemia 01/2018 - 11/2002
3	Hemorrhage 11/2013 - 08/2002
3	Reperfusion Injury 08/2013 - 06/2003
3	Multiple Sclerosis 12/2009 - 10/2008
3	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2009 - 05/2002
3	Respiratory Hypersensitivity 10/2005 - 01/2002
2	Infections 11/2019 - 01/2019
2	Malaria 07/2019 - 06/2004
2	Ureteral Obstruction 01/2019 - 01/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 01/2019
2	Lung Injury 12/2017 - 05/2003
2	Acute Lung Injury 08/2014 - 08/2002
2	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2014 - 10/2004
2	Myocardial Ischemia (Ischemic Heart Diseases) 05/2012 - 05/2009
2	Peripheral Nerve Injuries 05/2010 - 10/2008
2	Insulin Resistance 04/2010 - 06/2003
2	Idiopathic Pulmonary Fibrosis 12/2009 - 05/2002
2	Osteoporosis 03/2008 - 07/2004
2	Rheumatoid Arthritis 03/2008 - 10/2004
2	Pneumococcal Pneumonia 01/2006 - 02/2004
2	Lissencephaly 11/2005 - 08/2003
2	Brain Injuries (Brain Injury) 08/2004 - 08/2002
1	Emphysema 08/2022
1	Pulmonary Emphysema 08/2022
1	Chronic Obstructive Pulmonary Disease (COPD) 08/2022

Drug/Important Bio-Agent (IBA)

18	LipidsIBA 01/2019 - 07/2003
13	Platelet Activating FactorIBA 01/2021 - 01/2002
13	EnzymesIBA 01/2019 - 05/2002
13	Phospholipases (Phospholipase)IBA 01/2015 - 05/2002
13	platelet activating factor receptorIBA 09/2013 - 01/2002
12	Leukotriene B4IBA 01/2018 - 08/2002
10	Proteins (Proteins, Gene)FDA Link 12/2021 - 11/2005
9	Leukotriene B4 Receptors (Leukotriene B4 Receptor)IBA 01/2019 - 10/2005
6	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2021 - 10/2004
6	CytokinesIBA 01/2019 - 05/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2014 - 06/2003
4	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 06/2002
4	Antiviral Agents (Antivirals)IBA 05/2020 - 12/2018
4	CollagenIBA 01/2019 - 05/2002
4	Biological ProductsIBA 03/2015 - 03/2005
4	Arachidonic Acid (Vitamin F)IBA 10/2012 - 07/2010
4	Immunoglobulin G (IgG)IBA 05/2012 - 04/2008
4	EicosanoidsIBA 12/2011 - 05/2002
4	Prostaglandins EIBA 07/2010 - 05/2003
3	1-Acylglycerophosphocholine O-Acyltransferase (1 Acylglycerophosphocholine O Acyltransferase)IBA 08/2022 - 01/2017
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 01/2019
3	wisteria lectinIBA 05/2020 - 12/2018
3	Carrier Proteins (Binding Protein)IBA 05/2020 - 12/2018
3	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 06/2003
3	Dinoprostone (PGE2)FDA Link 01/2015 - 05/2003
3	LipopolysaccharidesIBA 01/2015 - 05/2003
3	Group IV Phospholipases A2IBA 10/2012 - 09/2005
3	ProstaglandinsIBA 12/2009 - 05/2003
2	Chromogranin AIBA 06/2022 - 01/2014
2	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 01/2019 - 01/2015
2	Pharmaceutical PreparationsIBA 01/2019 - 05/2002
2	glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA 01/2019 - 01/2015
2	EndocannabinoidsIBA 01/2019 - 01/2015
2	Monoacylglycerol LipasesIBA 01/2019 - 01/2015
2	lysophosphatidic acidIBA 01/2018 - 01/2017
2	LeukotrienesIBA 01/2018 - 03/2008
2	Polychlorinated Dibenzodioxins (TCDD)IBA 01/2017 - 02/2014
2	Triglycerides (Triacylglycerol)IBA 01/2017 - 09/2009
2	Formaldehyde (Formol)FDA Link 03/2015 - 09/2007
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/2014 - 02/2010
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 02/2014 - 02/2010
2	IgG Receptors (Fc gamma RI)IBA 03/2012 - 04/2011
2	Immunoglobulin E (IgE)IBA 03/2012 - 04/2008
2	Phospholipases A2 (Phospholipase A2)IBA 12/2011 - 05/2003
2	Small Interfering RNA (siRNA)IBA 10/2010 - 07/2010
2	AdiponectinIBA 04/2010 - 06/2003
2	indium-bleomycinIBA 12/2009 - 05/2002
2	Bleomycin (Blenoxane)FDA LinkGeneric 12/2009 - 05/2002
2	oxidized low density lipoproteinIBA 01/2008 - 10/2004
2	Cholinergic Agents (Cholinergics)IBA 06/2004 - 01/2002
2	modipafantIBA 06/2003 - 03/2002
1	1,2-Dipalmitoylphosphatidylcholine (Dipalmitoylphosphatidylcholine)IBA 08/2022
1	Pancreatic Elastase (Elastase)IBA 08/2022
1	SmokeIBA 08/2022
1	Surface-Active Agents (Surfactants)IBA 08/2022

Therapy/Procedure

7	Therapeutics 09/2020 - 12/2009
3	Pancreaticoduodenectomy 11/2014 - 11/2013
2	Laparotomy 06/2022 - 02/2003
2	Ligation 01/2017 - 09/2008
2	Drug Therapy (Chemotherapy) 11/2012 - 04/2005
2	Ovariectomy (Oophorectomy) 12/2009 - 07/2004